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|Title:||Intracellular delivery of biologic therapeutics by bacterial secretion systems|
|Keywords:||Immunology;0601 Biochemistry And Cell Biology|
|Publisher:||Cambridge University Press (CUP)|
|Description:||Biologics are a promising new class of drugs based on complex macromolecules such as proteins and nucleic acids. However, delivery of these macromolecules into the cytoplasm of target cells remains a significant challenge. Here we present one potential solution: bacterial nanomachines that have evolved over millions of years to efficiently deliver proteins and nucleic acids across cell membranes and between cells. In this review, we provide a brief overview of the different bacterial systems capable of direct delivery into the eukaryotic cytoplasm and the medical applications for which they are being investigated, along with a perspective on the future directions of this exciting field.|
|Type Of Material:||OTHER|
|Appears in Collections:||Bioengineering|
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