جهت دسترسی به کاربرگه ی زیر، از این لینک استفاده کنید. http://dl.pgu.ac.ir/handle/Hannan/57636
Title: Intracellular delivery of biologic therapeutics by bacterial secretion systems
Keywords: Immunology;0601 Biochemistry And Cell Biology
Issue Date: 25-Feb-2017
Publisher: Cambridge University Press (CUP)
Description: Biologics are a promising new class of drugs based on complex macromolecules such as proteins and nucleic acids. However, delivery of these macromolecules into the cytoplasm of target cells remains a significant challenge. Here we present one potential solution: bacterial nanomachines that have evolved over millions of years to efficiently deliver proteins and nucleic acids across cell membranes and between cells. In this review, we provide a brief overview of the different bacterial systems capable of direct delivery into the eukaryotic cytoplasm and the medical applications for which they are being investigated, along with a perspective on the future directions of this exciting field.
Other Identifiers: 1462-3994
http://hdl.handle.net/10044/1/45042
EP/K038648/1
EP/M002187/1
Type Of Material: OTHER
Appears in Collections:Bioengineering

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