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Title: Localized and controlled delivery of nitric oxide to the conventional outflow pathway via enzyme biocatalysis: towards therapy for Glaucoma
Keywords: glaucoma;layer-by-layer capsules;liposomes;nitric oxide;??-galactosidase;Nanoscience & Nanotechnology;02 Physical Sciences;03 Chemical Sciences;09 Engineering
Issue Date: 21-Feb-2017
Publisher: Wiley
Description: Nitric oxide (NO) has been shown to lower intraocular pressure (IOP), however its therapeutic effects on outflow physiology are location- and dose-dependent. Here, a NO delivery platform that directly targets the resistance-generating region of the conventional outflow pathway and locally liberates a controlled dose of NO is reported. An increase in outflow facility (decrease in IOP) is demonstrated in mouse model.
Other Identifiers: 1521-4095
Type Of Material: OTHER
Appears in Collections:Bioengineering

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