جهت دسترسی به کاربرگه ی زیر، از این لینک استفاده کنید. http://dl.pgu.ac.ir/handle/Hannan/41311
Title: Protein Arms in the Kinetochore-Microtubule Interface of the Yeast DASH Complex
Issue Date: 2007
Publisher: American Society for Cell Biology
Description: The yeast DASH complex is a heterodecameric component of the kinetochore necessary for accurate chromosome segregation. DASH forms closed rings around microtubules with a large gap between the DASH ring and the microtubule cylinder. We characterized the microtubule-binding properties of limited proteolysis products and subcomplexes of DASH, thus identifying candidate polypeptide extensions involved in establishing the DASH-microtubule interface. The acidic C-terminal extensions of tubulin subunits are not essential for DASH binding. We also measured the molecular mass of DASH rings on microtubules with scanning transmission electron microscopy and found that approximately 25 DASH heterodecamers assemble to form each ring. Dynamic association and relocation of multiple flexible appendages of DASH may allow the kinetochore to translate along the microtubule surface.;Molecular and Cellular Biology
URI: http://nrs.harvard.edu/urn-3:HUL.InstRepos:3109301
Other Identifiers: Miranda, JJ L., David S. King, and Stephen C. Harrison. 2007. Protein arms in the kinetochore-microtubule interface of the yeast DASH complex. Molecular Biology of the Cell 18, no. 7: 2503-2510.
1059-1524
Appears in Collections:Faculty of Arts and Sciences

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