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Title: 6-exo-trig Michael addition-lactonizations for catalytic enantioselective chromenone synthesis
Keywords: QD Chemistry;TP Chemical technology;QD;TP
Issue Date: 28-Feb-2017
Description: The authors thank the EPSRC Centre for Doctoral Training in Critical Resource Catalysis (CRITICAT, grant code EP/L016419/1, RMNP) for funding.The European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013) ERC Grant Agreement No. 279850 is also acknowledged. ADS thanks the Royal Society for a Wolfson Research Merit Award;The catalytic enantioselective 6-exo-trig Michael addition-lactonization of enone-acid substrates to form cis-chromenones with high diastereo- and enantiocontrol was developed using the commercially available isothiourea tetramisole. An acidic workup proved necessary to minimize product epimerization and maximize product er, providing cis-chromenones in excellent yield, and with excellent diastereo- and enantioselectivity.;Publisher PDF;Peer reviewed
Other Identifiers: N P , R M , Cordes , D B , Slawin , A M Z & Smith , A D 2017 , ' 6-exo-trig Michael addition-lactonizations for catalytic enantioselective chromenone synthesis ' Chemical Communications , vol 53 , no. 17 , pp. 2555-2558 . DOI: 10.1039/C6CC10178J
PURE: 248996963
PURE UUID: 7e332261-8787-4384-9d07-0cf857a59ab2
Type Of Material: OTHER
Appears in Collections:Chemistry (School of)

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